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About Artists for Humanity EpiCenter

Welcome to the Artists for Humanity EpiCenter, a environmentally conscious, multi-space event venue and art gallery in Boston’s Seaport area. Operated by Artists For Humanity (AFH), the EpiCenter combines creative spaces with flexible layouts for a wide range of events—from intimate receptions to larger gatherings. The venue is LEED Platinum–certified, reflecting its commitment to sustainability, community, and accessible art.

With a total space exceeding 23,000 square feet, AFH EpiCenter offers distinct spaces for different experiences, including the Lewis Gallery and the AFH Gallery, each with its own seating and standing configurations. We’ve got you covered with detailed seating options, parking guidance, transit access, and nearby hotel and dining recommendations to help you plan a smooth, hassle-free event in Boston.

When you’re ready to secure your date, we’ll guide you through the space options, availability, and how to make AFH EpiCenter your next memorable gathering.

Venue spaces and capacity
AFH EpiCenter provides flexible configurations across its spaces: Lewis Gallery (up to 450 standing or 250 seated) and AFH Gallery (up to 150 seated or 250 standing). The combined venue accommodates large cocktail receptions of up to 800, with the full venue offering expansive versatility for events, exhibitions, and performances. Seating and floor plans vary by space, so we’ll tailor the setup to your event needs.

Parking and transportation
Street parking and valet options are available nearby. The Channel Center Garage is located at 116 W First St, a convenient option for guests. The EpiCenter sits close to the Broadway MBTA Station on the Red Line, offering easy access for attendees traveling from across the city and region.

Nearby hotels and dining
Find comfortable stays and dining options nearby. Recommended options include the Cambria Hotel Boston Downtown – Seaport (6 West Broadway), Element Boston Seaport District, and The Envoy Hotel in the Seaport District. We partner with select hotels and restaurants to provide reliable recommendations for your guests, with convenient proximity to the venue for after-hours plans or overflow accommodations.

Notable events at AFH EpiCenter
The venue hosts a variety of events, including Gilt City Boston Warehouse Sale, performances and programs by the Celebrity Series of Boston, and AFH Open Studio/Artopia-type events. The space continues to serve as a hub for community art, youth-driven projects, and engaging experiences in Boston.

How to secure your event
We’ve got you—contact us to explore space options, availability, and capacity planning. We’ll help secure your seats and coordinate logistics, ensuring a straightforward, reliable booking process for your next Boston-area event.

Good to know

Seating, Parking & Venue Information

  • Address: 100 West 2nd Street, Boston, MA 02127.
  • Venue type: LEED Platinum–certified, environmentally friendly multi-space event venue and art gallery operated by Artists For Humanity (AFH).
  • Capacity: up to 800 for cocktail receptions; Lewis Gallery capacity up to 450 (standing) or 250 (seated); AFH Gallery capacity up to 150 seated or 250 standing; total space over 23,000 sq ft.
  • Seating/chart: Spaces include Lewis Gallery and AFH Gallery with separate seating/standing configurations; multiple event spaces available (as per space breakdowns).
  • Parking & transit: Street parking and valet options; nearby Channel Center Garage (116 W First St); located near the Broadway MBTA station (Red Line).
  • Nearby hotels: Cambria Hotel Boston Downtown – Seaport (6 West Broadway); Element Boston Seaport District; The Envoy Hotel (Seaport District).
  • Notable events hosted: Gilt City Boston Warehouse Sale; Celebrity Series of Boston events; Victim Rights Law Center’s Shining Star Celebration (and other AFH Open Studio/Artopia-type events).
  • Demolished/renamed: No demolition or official renaming; AFH continues to operate the EpiCenter as a venue (the space is marketed as AFH EpiCenter).