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The venue

About Osage Centre

Osage Centre is Cape Girardeau’s premier 52,000 sq ft multi‑purpose venue, built to host a wide range of events—from health expos and arts festivals to dance festivals and community sales. With a flexible main floor and six meeting rooms, this venue adapts to your event needs. There’s no fixed seating chart, so configurations are event‑driven to maximize sightlines and audience comfort. We’ve got you covered with straightforward booking, parking details, transit options, and nearby hotel and dining recommendations to help you plan a smooth visit.

Whether you’re organizing a community expo, a large family gathering, or a regional championship, Osage Centre provides ample on‑site parking and easy access via the Cape Girardeau Transit Authority fixed‑route service. Nearby hotels offer convenient stays for out‑of‑town guests, and nearby restaurants provide a range of options to fuel your day. If you’re securing tickets for an Osage Centre event, trust us to guide you through ticket options, availability, and the best way to reach the venue.

Good to know

Seating, Parking & Venue Information

  • Address: 1625 N Kingshighway, Cape Girardeau, MO 63701.
  • Venue type: 52,000 sq ft multi‑purpose facility; main floor is 16,677 sq ft and can be two basketball courts or four volleyball courts; six meeting rooms; concessions/caterer prep area.
  • Seating/chart: No fixed seating chart—configuration is event‑driven (main floor Rentals and room layouts are described in the Osage Centre brochures).
  • Parking: On‑site parking with ample space (described as ample parking in external venue listings).
  • Transit: Cape Girardeau Transit Authority fixed‑route service operates in the area.
  • Nearby hotels: Drury Plaza Hotel Cape Girardeau Conference Center (3351 Percy Dr); Drury Inn & Suites Cape Girardeau (3303 Campster Dr); Pear Tree Inn Cape Girardeau West (103 Cape West Pkwy); Holiday Inn Express & Suites Cape Girardeau I‑55 (3253 William St).
  • Notable events hosted: Health Expo (2025) at Osage Centre; Arts & Crafts Extravaganza (Arts Council of Southeast Missouri); Missouri Square & Round Dance Festival; Cape Girardeau garage sales hosted at Osage Centre.