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The Main Room at DNA Lounge Tickets
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The venue
About The Main Room at DNA Lounge
The Main Room at DNA Lounge is a dynamic, two‑story 3,000 sq ft venue tucked inside the DNA Lounge complex at 375 11th Street in San Francisco. With a standing capacity of about 800 and 72 fixed seats, it’s a go-to spot for energetic live shows, dance nights, and one‑of‑a‑kind events like the weekly Bootie Mashup. The Main Room sits within a multi‑room venue that also includes The Lounge (roughly 300 standing) and Above DNA (roughly 300 standing), giving guests a flexible layout for performances and immersive experiences.
Whether you’re catching a headline performance, a club night, or a private event, we’ve got you covered with practical details on seating, parking, transit, and nearby hotel and dining options to help you plan a smooth night out in San Francisco’s SOMA district.
Tips for a great visit: secure your seats when you can, arrive early for the best viewing options, and take advantage of nearby transit options—BART stops at Civic Center/UN Plaza or Powell Street are within a half‑mile, and several Muni bus lines serve the area (including 14R, 27, 9, and 9R). If you drive, street parking is limited, but nearby garages like SOMA Hub (255 12th St) and Costco Garage (450 10th St) can be convenient options. For visitors staying overnight, a range of budget-friendly hotels and inns are within roughly 0.5 miles, with affiliate partner recommendations below to help you compare options and secure your stay. The venue has a history of notable events—from the enduring Bootie Mashup nights to celebratory anniversaries like the DNA Lounge 40th Anniversary in 2025—making it a staple of San Francisco’s nightlife scene.
Good to know
Seating, Parking & Venue Information
- Location and venue type: The Main Room is within DNA Lounge, a multi‑room nightclub/restaurant at 375 11th Street, San Francisco, CA 94103.
- Capacity and seating: Main Room standing capacity ~800; fixed seating ~72 (72 seats total historically cited for the Main Room).
- Layout: Main Room is a 3,000 sq ft, two‑story space with a balcony; other spaces in the complex include The Lounge (approx. 300 standing) and Above DNA (approx. 300 standing).
- Parking: Street parking is limited; nearby garages exist (e.g., SOMA Hub at 255 12th St and Costco Garage at 450 10th St; SpotHero listings).
- Transit: Public transit options include BART stops within a half‑mile (Civic Center/UN Plaza or Powell Street) and nearby Muni bus lines (e.g., 14R, 27, 9, 9R).
- Nearby hotels: Several budget/2‑star options are listed within ~0.5 miles (e.g., Civic Center Motor Inn, San Francisco Inn, Inn on Folsom, SOMA Park Inn, Americas Best Value Inn SOMA, City Center Inn & Suites).
- Notable events hosted: Bootie Mashup nights (weekly on Saturdays); DNA Lounge 40th Anniversary event in 2025 (Meat vs. Death Guild + more); NYE Bootie events in the past; the space has hosted multi‑room corporate and private events as well.
- Demolished/renaming status: The Main Room has not been demolished or renamed; DNA Lounge expanded in 2012 to include DNA Pizza, integrating adjacent space into the venue.